BRD4 inhibitor Compound V
CAS No.
BRD4 inhibitor Compound V ( —— )
Catalog No. M17061 CAS No.
BRD4 inhibitor Compound V is a domain-selective inhibitor of BRD4 with IC50 of 1.8 uM for BRD4 BD1, displays 6- and 16-fold selectivity for BRD4 over BRD2 and BRD3, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameBRD4 inhibitor Compound V
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NoteResearch use only, not for human use.
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Brief DescriptionBRD4 inhibitor Compound V is a domain-selective inhibitor of BRD4 with IC50 of 1.8 uM for BRD4 BD1, displays 6- and 16-fold selectivity for BRD4 over BRD2 and BRD3, respectively.
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DescriptionBRD4 inhibitor Compound V is a domain-selective inhibitor of BRD4 with IC50 of 1.8 uM for BRD4 BD1, displays 6- and 16-fold selectivity for BRD4 over BRD2 and BRD3, respectively; demonstrates reduction of c-Myc expression, inhibition of NF-κB signaling, and suppression of IL-8 production through potential synergistic inhibition of BRD4(1) and p38α.
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Synonyms——
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PathwayChromatin/Epigenetic
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TargetBromodomain
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RecptorBromodomain
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Research Area——
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Indication——
Chemical Information
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CAS Number--
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Formula Weight442.54
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Molecular FormulaC26H27FN6
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical NameN-(3,5-dimethylphenyl)-4-(4-(4-fluorophenyl)-1-(piperidin-4-yl)-1Himidazol-5-yl)pyrimidin-2-amine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Anand Divakaran, et al. J. Med. Chem., 2018, 61 (20), pp 9316-9334.
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